Uneven skin tone study, 2011

Trial centre

Thomas J. Stephens & Associates, Inc., Texas, United States of America.

Objective

To evaluate the efficacy of Bi-Oil in improving the appearance of uneven skin tone and mottled pigmentation when used by women with mild to moderate photodamaged (aging) skin on the face and neck.

Sample

Subjects: 67 female participants (of varying ethnicities) with clinically determined mild to moderate photodamage on the face and neck. Bi-Oil treatment cell included 35 subjects and the no treatment cell included 32 subjects. Age of participants: 30 to 70.

Methodology

Randomized, controlled, efficacy grader-blinded. Subjects participated in an initial screening evaluation followed by a 1-week washout period. Product applied to the face and neck twice daily for 12 weeks. Application performed under supervision at baseline visit. Clinical evaluations conducted at 0, 2, 4, 8 and 12 weeks. Subjects were clinically graded separately on the face and neck for uneven skin tone and mottled pigmentation.

Result

Bi-Oil is efficacious in improving the appearance of uneven skin tone and mottled pigmentation in photodamaged (aging) skin. After 4 weeks a statistically significant result was achieved for both parameters on the face and neck. After 12 weeks 86% of subjects in the Bi-Oil treatment cell showed a statistically significant improvement in uneven skin tone on the face, 71% of subjects in mottled pigmentation on the face, 69% in uneven skin tone on the neck and 60% in mottled pigmentation on the neck.