Uneven skin tone study, 2005

Trial centre

Photobiology Laboratory of the Medical University of South Africa.


To assess the efficacy of Bi-Oil in improving the appearance of uneven skin tone.


Subjects: 30 female participants of varying ethnicities. Age of participants: 18 to 55. Pigmentation type: facial melasma.


Single-blind (assessor), randomized and controlled. Paired study design allowing for intra-subject comparison. Subjects had bilateral pigmentation, enabling half-face/neck study design. Product applied twice daily for 12 weeks to the targeted area. Application performed under supervision at regular intervals. Assessments conducted at 0, 4, 8 and 12 weeks.


Bi-Oil improved the appearance of uneven skin tone in both light and dark skin types. 93% of subjects recorded an improvement in appearance at 6 weeks. Clinician noted an equal improvement in both light and dark skin types from week 0 to 8. Clinician noted more improvement in dark skin types from week 8 to 12.